Biological Age: The Single Greatest Biomarker For A Long And Disease-Free Life
Biological age is a critically under-examined health marker for assessing your overall health and longevity.
What gets measured gets improved, and it is mission-critical to track and optimize your biological age.
After all, living longer is pointless if you are spending every waking second with chronic diseases that are ruining your quality of life.
In this blog post, you’re going to learn that your health has NOTHING to do with how old you are.
More importantly, you’ll learn why biological age is important and how you can start tracking it today.
What Is the Difference Between Chronological Age And Biological Age?
To understand the significance of biological age, it is important to understand how it is separate from your chronological age.
Your chronological age is simply how old you are — nothing more, nothing less.
And although you can be in great shape or health at any age, aging is generally considered to be a major health problem:
“Aging is a complicated process characterized by progressive decline in physical, mental, and reproductive capacities, leading to a loss of function, increased susceptibility to disease, and ultimately the end of life”
“…life expectancy shows considerable variation among individuals with equal or similar CAs due to diversity in genotypes and in living habits and environments.
A 50-year-old individual may have 60-year-old body functions, and many people look older or younger compared to others at the same CA (even in twins).Therefore, CA is not an optimal indicator for the aging progress.”
“Among the top 43 most common health conditions and behaviors in our cohort, after correcting for multiple comparisons, obesity, hypertension, high cholesterol, lung infection, type 2 diabetes (T2D), and breast cancer were associated with increased ΔAge in models adjusted for [chronological age] and obesity”
Take a look at the picture below, which comes from the study I just quoted:
“ΔAge” in this picture is defined as “chronological age subtracted by biological age”
(A positive ΔAge means your biological age is older than your chronological age, while a negative ΔAge means your biological age is younger than your chronological age)
In all 43 disease states, having an older biological age is bad news.
“A small clinical study in California has suggested for the first time that it might be possible to reverse the body’s epigenetic clock, which measures a person’s biological age.
For one year, nine healthy volunteers took a cocktail of three common drugs — growth hormone and two diabetes medications — and on average shed 2.5 years of their biological ages, measured by analysing marks on a person’s genomes. The participants’ immune systems also showed signs of rejuvenation.”
Things such as maintaining a healthy body fat percentage, eating a clean diet, getting regular exercise, managing stress, avoiding environmental toxins, and sleeping 7-8 hours per night can do wonders for lowering your biological age.
The conclusion is simple: Lower your biological age as much as possible and you will achieve a state of optimal health.
To use an analogy, imagine biological age as the final grade you get after taking a class.
Measuring other health metrics such as your inflammatory markers would be equivalent to the marks you get on tests and assignments that add up towards your final grade.
What Is The Best Way To Measure Biological Age?
How do we go about measuring our biological age in the most accurate and efficient way possible?
This mystery has been pursued by scientists for decades, examining different biomarkers that do the best possible job of expressing our biological age in numerical terms.
According to the American Federation for Aging Research, a biomarker for biological aging must meet four specific criteria:
“1. It must predict the rate of aging. In other words, it would tell exactly where a person is in their total life span. It must be a better predictor of life span than chronological age.
2. It must monitor a basic process that underlies the aging process, not the effects of disease.
3. It must be able to be tested repeatedly without harming the person. For example, a blood test or an imaging technique
4.It must be something that works in humans and in laboratory animals, such as mice. This is so that it can be tested in lab animals before being validated in humans.”
“…the epigenetic clock appears to be associated with a wide spectrum of aging outcomes, most consistently mortality. Its predictability is observable in several different tissues, suggesting a pervasive, systems-level mechanism.”
On top of measuring the rate at which you are aging, your epigenetic clock can make a clear distinction between your chronological age and your biological age.
“DNA methylation occurs naturally when a methyl group – a chemical structure containing three carbon atoms and one hydrogen atom – attaches to one of DNA’s four nucleotide bases (adenine [A], cytosine [C], guanine [G], or thymine [T]).
The most common DNA methylation process involves the addition of a methyl group to one of the carbon atoms in the cytosine base, forming 5-methylcytosine…The majority of 5-methylcytosine is found on areas of the DNA known as CpG islands – short stretches of DNA where the frequency of the cytosine-guanine (CG) sequence is higher than other regions”
Let me tell you the implications of all that complicated science…
DNA methylation is a double-edged sword.
While it is essential to selectively turn certain genes on and off for your development in the womb and beyond, DNA methylation can also lead to several disease states.
Which leads us to asking several critical questions…
Is there any DNA methylation test in existence that can tell us EXACTLY where an excess or lack of DNA methylation is taking place in our genome?
And can this same test provide us with actionable information to determine the changes we need to start making in our lives?
The ONLY Biological Age Test You Should Be Using
If you’re looking for a truly advanced epigenetic DNA methylation test for tracking your biological age with unrivaled precision and accuracy, I would highly recommend checking out TruDiagnostic.
Taken directly from their website:
“TruDiagnostic™ is a state-of-the-art epigenetics diagnostic company that offers diagnostics for clinical practitioners and their patients hoping to read their DNA methylation patterns to help diagnose and affect health outcomes.”
Since they use the most advanced deep-learning algorithms powered by artificial intelligence, you are getting your hands on a test which is far more comprehensive than anything in the market.
Whereas most tests will use 2,000 spots on the human genome or less, TruDiagnostic uses 850,000 spots — 425 times MORE than any leading competitor!
They also use blood samples, which are the best way to precisely track DNA methylation levels and provide you with better data.
But all of those things pale in comparison to the most important part of their TruAge diagnostic kit.
TruAge tells you how long you can expect to live, along with your likelihood of contracting certain diseases.
The information you get from your test puts you in a position of power to take preventative action before your health starts decaying.
This is a far-cry from common DNA testing companies such as 23AndMe and Ancestry.com, which only spit out your sequence and put the burden on you to figure out the implications.
(You’ll avoid using their inferior saliva testing methods, AND avoiding the privacy invasions frequently reported with both companies)
While other tests are certainly important, TruAge gives you a single objective measurement that provides individualized guidance for addressing your health concerns.
How To Use TruAge For The Best Results Possible
TruAge is one of the easiest blood tests you’ll ever encounter in your lifetime.
All you have to do is order the TruAge kit, which arrives at your home within 3-5 business days.
Follow the instructions on the kit and send your sample back to the TruDiagnostic lab.
Your results will be accessible online within 6-8 weeks, where you will discover your biological age and potential suggestions for lowering it.
I hate to say it, but it’s really that simple!
If you want more detailed information about how your sample gets processes in their diagnostic laboratories, go here.
Where To Order Your Own TruAge Diagnostic Kit
For all of my loyal readers and subscribers, I am offering a $50 discount when you use the code “JC50” at the checkout cart.
“…a revolutionary device from Launch Medical that uses sound wave therapy to permanently reverse symptoms of ED (erectile dysfunction).
It utilizes the same technology employed by ED clinics worldwide but has made the enhancement of sexual performance far more affordable, with a retail price of $749—while eliminating the stress, embarrassment and anxiety of conventional medical office visits.”
No downtime, no invasive surgery, no drugs, no pain, and no side effects.
This is a portable device meant to dramatically improve your sex life and enhance your sexual performance, all from the comfort and convenience of your own home.
Fuller, thicker, and possibly bigger erections await any man who uses this golden age technology.
It may be the perfect solution for men who are suffering from Peyronie’s disease or erectile dysfunction.
But it is equally effective for men who want to be as sexually optimized as possible.
Put simply: If you are a man who is active in the bedroom, choosing to own this device will greatly help your bedroom performance.
I’ve already written two high-level blog posts that talk about The Rocket in greater detail.
The first one I wrote gives you a full and complete explanation of the technology powering The Rocket.
The second one includes my personal experience with using The Rocket (and a must-see video where I do a treatment on myself).
I also have several videos and podcasts about The Rocket for people who are unaware of this life-altering device and what it can do for them:
Why Didn’t The Rocket Ship Out On Time?
My long-time readers placed orders for the Rocket in late 2019 for $399 when it first launched, and some of them paid the full price of $749 since the pre-order deadline.
Launch Medical, the company who created the product, promised to have all orders shipped out by the end of January.
But there were two major events that significantly delayed the manufacturing and delivery process.
Reason #1: COVID-19 Disrupted Manufacturing In China
Even though I have written prolifically about the spread of COVID-19, one area I did not touch upon was how the virus affecting manufacturing worldwide.
This is important because the manufacturer of The Rocket was an American-owned manufacturer based in China.
They are responsible for handling the production for several prestigious companies such as Tesla.
“China’s consumer spending and factory activity fell more than expected in January and February as it fought a virus outbreak, prompting some forecasters to warn this year’s economic growth might slump to its lowest level since the 1970s.”
“…Factory output declined by a record 13.5 per cent after the Lunar New Year holiday was extended to keep manufacturing employees at home.
The unexpectedly bleak figures suggest the world’s second-largest economy is shrinking despite the ruling Communist Party’s efforts to revive manufacturing and other industries, some forecasters said.”
“Unfortunately, at this time we are unable to ship the “Rocket” product because Mark White’s company, Sexual MD Solutions LLC., the owner of GAINSWave, has obtained a preliminary legal injunction preventing the shipping of a product named the ‘Rocket’.”
The judge overseeing the case granted an injunction in favor of GAINSWave.
Here’s what this means…
The lawsuit effectively prevented any selling, marketing or licensing of The Rocket.
All of Launch Medical’s marketing materials, sales funnels, and affiliate systems CAN NOT be used anymore.
Dustin and Stephanie Wolff, the co-founders of Launch Medical, are no longer allowed to be involved in anything that bears the name “The Rocket”.
They were also barred from externally communicating with people due to the lawsuit, which is why they have been unresponsive to many customer complaints.
They were bound by the confines of the law and could not do anything about it even right now.
The one saving grace in the situation was Jon Hoffman, the PATENT HOLDER of The Rocket and the third co-founder of Launch Medical was given freedom to do whatever he wants.
The document pertaining to the public lawsuit gives Jon the legal freedom to rebrand The Rocket under a different name entirely:
“The injunction will not prohibit non-party Jon Hoffman from independently marketing and selling the Rocket under a different name…”
But Jon has now been challenged with a difficult task.
Not only can he no longer coordinate with Dustin or Stephanie, or use any of the sales materials they developed, but he also does not have access to the list of people who have already bought a Rocket.
So he has taken the necessary steps to rebrand The Rocket as The Phoenix.
As he told me in a private conversation, “The Phoenix Will Rise Again!”
I made a summary video detailing this entire situation in five short minutes:
The Immediate Future Of The Phoenix
Jon and his team have been working around the clock to get the new website up and start fulfilling orders.
That time is now:
The Phoenix is IN STOCK and Shipping everywhere including internationally..
Please be patient as they are dealing with a tidal wave of refunds.
Everyone will be processed and taken care of but patience is required.
Once you get your refund, the next step is to send an email to firstname.lastname@example.org that provides a photo of your receipt and explain the deal you had with Launch Medical at the time of purchase (ideally via a screenshot).
Communicate the deal you agreed upon when you purchased The Rocket and provide them with as much information as possible.
DO NOT ask them for a refund as they cannot legally process it.
They will then send you an email with a special link for you to purchase at your initial acquisition price.
They will also honor any other special deal you were offered (BOGO or additional ancillaries).
Please be patient as they continue to work through the deals and refunds.
It has also recently come to the attention of support personnel that many buyers of the Rocket are complaining their messages are not being responded by Launch Medical in a fast enough fashion.
Please make sure you are checking your spam folders as emails are responded to immediately.
I was personally asked by Jon Hoffman himself to relay his quote to my readers:
“We will absolutely honor any deals you had for a Rocket, including a free second device.
Please bear in mind that while supplies are somewhat limited due to us fulfilling orders for initial purchasers, we truly are in full production mode and will very soon have more than enough devices for anybody who ordered a Rocket previously as well as all new customers.
We are not going to let anybody keep this disruptive technology from the people who want it, need it, and deserve it.
We are democratizing erections!
Here’s What To Do If You DID NOT Purchase The Rocket & Want to Purchase The Phoenix Now:
The Phoenix is in stock and shipping everywhere now!
“Nuritas’ Peptide Finder (ΝΠΦ) Platform combines a database with years of experiments on thousands of peptides with state-of-the-art machine learning (ML) architecture that can identify peptides active against a target or pathway of interest.”
“They will have two projects focusing on COVID-19 peptide identification: one for identifying antiviral peptides that target how SARS-CoV-2 hijacks cells, and one for identifying peptides that locally reduce lung inflammation without suppressing the entire immune system.”
But where did the interest in therapeutic peptides come from?
Who came up with the genius idea to use them in the first place?
A Brief History On The Use Of Peptides In Medicine
“Starting about a century ago (World War I), the advent of the modern drug era came with pioneering therapeutic compounds like the opiatemorphine and the cyclic peptidepenicillin, followed in the early 1920s by the (poly)peptide insulin.”
However, small molecules were much easier to manufacture and administer for the pharmaceutical industry, which is why they were favored over peptides.
But this quickly worked against them — combined with the cost needed to bring one to the market and increasingly strict regulations, alternative solutions were needed:
“Fewer new drugs make it to the market and the patent protection of current blockbuster drugs is deteriorating, with a resulting drainage of the drug pipelines.
All this may ultimately push the pharmaceutical industry towards a new frontier in modern drug development.”
“Antibodies excel at target binding and PPI disruption with potency and specificity.
However, they carry certain liabilities, including an inability to access intracellular targets, poor tissue penetration, complex manufacturing and storage, immunogenic potential, and limitations to targets of sufficiently poor homology in host animals for B cell reactivity.”
Keep in mind that peptides are distinct from proteins, which are larger (>50 amino acids) and spontaneously rearrange into different structures.
Why Are Therapeutic Peptides So Versatile?
There are numerous reasons why peptides are being heavily used by optimization doctors who want to provide better care for their patients.
You can also gain lean muscle, slow down aging, strengthen the immune system, increase IQ, lose stubborn body fat, and treat major diseases such as chronic inflammation, Alzheimer’s, traumatic brain injury, and much more!
Therapeutic Peptides Can Be Administered In Several Ways
While each peptide will have an “optimal” form of delivery, there are several methods for administering them.
You can inject them subcutaneously or intramuscularly.
Some of them can even be taken as an oral pill, like the muscle-building agent (small molecule) 5-Amino 1MQ.
Therapeutic Peptides Can Be Created Naturally Or Synthetically
Many of the peptides I have talked about are naturally produced by the body, which is why they tend to work so well with very few side effects.
Other peptides can be synthetically created in a lab, and many leading research teams have worked tirelessly to make them in a way that is both quick and cost-effective:
“Unfortunately the FDA has implemented regulatory changes in the definition of a peptide less than 40 amino acid long and a ‘biological product’.
One compound pharmacy has been restricted in compounding peptides like BPC-157, MOTS-c, Semax and other peptides.
It is predicted that other compound pharmacies will no longer be able to compound peptides since the peptides are not on the Bulk Compounding List (503a) although they have been nominated to be on the list.”
Doctors are fighting to enact policy change that allows the use of peptides for medical purposes, as the FDA is purposely rushing very few hearings without any public input.
The best way for you to help them is to visit SavePeptides.org and have your voice heard!
A Few Therapeutic Peptides You MUST Know About
To tell you about every single therapeutic peptide in existence would be going way beyond the scope of this article.
That privilege is being reserved for my upcoming therapeutic peptide book being released this year.
But in the meantime, here are some of the most prominent ones worth your attention…
Peptides For Fat Loss
AOD9604, short for “Advanced Obesity Drug”, is a modified form of amino acids #176-191 at the C-terminus of the human growth hormone (hGH) peptide.
Making up less than 10% of the total peptide, this small section appears to control the fat-reducing effects attributable to hGH.
In other words, AOD9604 induces fat loss without the side effect of insulin resistance (seen in many other peptides that stimulate growth hormone).
Tesamorelin and Ipamorelin are BY FAR the best two medications in existence for losing stubborn body fat, and I have extensive experience with using both peptides.
I made an in-depth YouTube video with step-by-step instructions for how to use them together:
Peptides For Muscle Gain
PEG-MGF (Pegylated Mechano Growth Factor) is a promising peptide for hormonally optimized people who want to add a big “boost” to their lean muscle gains.
To describe what it does in a single sentence: “It significantly improves recuperation, can help minimize the effect of DOMS, and also elicit increased protein synthesis for muscle hypertrophy.”
5-Amino 1MQ works by targeting NNMT (small molecule nicotinamide N-methyltransferase), which has a role in the regulation of nicotinamide (NA) and of the methionine cycle.
NNMT inhibition activates muscle stem cells and promotes the regeneration of aged muscle cells.
I have put on 9 pounds of lean mass after four weeks of using it, with ZERO changes to my current diet or training schedule.
Peptides For Skin Care
No other peptide deserves to be here more than GHK-Cu.
It Improves skin density and firmness, reduces fine lines and deep wrinkles, dramatically improve skin clarity, and tightens loose skin.
Many of my friends have noted its ability to treat sunburns, which is great for those of us who are fair-skinned.
GHK-Cu is a topical solution that works systemically, as you can apply it to any part of your body and heal the site of injury (no injections necessary).
I like this Peptide so much that I co-founded Aseir Custom to sell it.
Even better is that GHK-Cu combined with C-60 revolutionary regrows hair. (Our product is currently in the pipeline and arriving soon)
Peptides For Wound & Injury Healing
BPC-157 has been a favorite of mine, so much so that I have dedicated an entire article to this peptide.
As I said in the article, “It is extremely protective of numerous bodily systems, on top of possessing the ability to radically accelerate the healing process of several types of injuries [such as muscles, bones, tendons and ligaments].”
TB-500 is another healing acceleration recovery peptide which is slightly better than BPC-157 for healing muscle injuries.
Just like BPC-157, it can be injected anywhere in the body (rather than directly at the site of injury).
Since both peptides work synergistically, you can take them at the same time and further speed up your body’s natural rate of healing.
Peptides For Improving Cognition
Dihexa is a powerful peptide derived from angiotensin IV that can actually repair brain damage instead of slowing down the rate at which it happens.
It is SEVEN TIMES more potent than BDNF, a neurochemical essential for forming new neural connections in the brain and allowing us to take in new information.
Not only can it potentially be used for treating Alzheimer’s, but it can also increase your mental stamina and long-term memory.
Semax is a ridiculously powerful nootropic, but it’s also cardioprotective, neuroprotective, neurorestorative, a powerful immune booster, and a nifty way to treat optic nerve disorder.
Like Dihexa, it can also lead to a big boost in the brain’s BDNF levels.
Its analog, N-Acetyl Semax, is a much more powerful variant due to its ability to cross the blood-brain barrier with greater ease.
Peptides For Sexual Health
PT-141 (a.k.a. Bremelanotide, “Vyleesi”) isa synthetic melanocortin analog that is derived from Melanotan 2 and is known as the world’s first FDA-approved aphrodisiac. (I will have an article that dives deeper about the merits of PT-141 in the coming weeks.)
Unlike other drugs meant for sexual health, it targets the region of the brain responsible for regulating sexual response, which makes it useful for both men and women.
But for the men reading this, it is phenomenal at increasing erection strength and duration.
Every Single Peptides Podcast I Have Ever Done
No blog post on peptides would possibly be complete without mentioning every single podcast I have ever done on the subject.
So here they are!
Why Peptides Are the Future of Medicine w/ Ryan Smith
This was the podcast that started my deep exploration into the world of therapeutic peptides. (I had been a user of Ipamorelin since 2007).
“Daniel Gwartney, MD, and colleagues at Baylor College of Medicine in Houston identified 1,578 professional male bodybuilders who compete from 1948 to 2014. They were able to obtain complete mortality data for 597.”
“…Of the 597 men, 58 (9.7%) were reported dead. Only 40 deaths were expected in this population based on age-matched data, for a standardized mortality rate of 1.34. The mean age of death was 47.7 years (range 26.6 – 75.4 years).”
“In the 1980s, Dr. Robert Goldman began asking top-level athletes if they’d accept a proverbial deal with the devil that guaranteed victory in every competition they entered… but also guaranteed their death within five years.
Goldman consistently found that the majority of athletes would eagerly accept the deal. It became known as ‘Goldman’s Dilemma.’”
Let me be as clear as possible in saying this…I DO NOT endorse the lifestyle of most competitive body builders.
As a former physique competitor myself (winner of various NPC contests and having consulted with numerous aspiring and pro bodybuilders over the last 2 decades)
I have massive respect for the amount of work, both in and out of the gym these men(and women)put in to build their phenomenal stage worthy physiques.
I consider it an honorable mission to help minimize the number of unnecessary bodybuilding injuries and deaths.
“Aromatase is a specific component of the cytochrome P450 enzyme system responsible for the transformation of androgen precursors into estrogens.
This enzyme is encoded by the CYP19A1 gene located at chromosome 15q21.2, that is, expressed in ovary and testis, but also in many extraglandular sites such as the placenta, brain, adipose tissue, and bone”
In other words, the correct testosterone-to-estrogen ratio for YOUR body is already genetically encoded and in constant regulation.
Everyone’s “sweet spot” is entirely dictated by biochemical individuality (due to your genetics) and your epigenetics (a.k.a. your lifestyle).
Therefore, attempting to get your estradiol (E2) levels to conform within ranges set forth by laboratory standards is a big fat waste of time.
(And by the way…the mean ranges provided by LabCorp and Quest Diagnostics are NOT designed for men using therapeutic testosterone!)
Blocking the aromatase enzyme is a terrible idea because you’re preventing your body from reaching a state of hormonal equilibrium between testosterone and estrogen levels:
“Men with estrogen deficiency caused by a mutation in the CYP19 gene suffer from low bone mineral density (BMD) and unfused epiphyses, and have high gonadotropin and testosterone levels.
As you can see, there are multiple disease pathologies possible when a genetic mutation causes estrogen deficiency.
Which leads me to the main takeaway of this section…
Anytime estrogen is attenuated, lowered, or blocked, pathology develops because estradiol is very protective in men.
Most of the beneficial effects of therapeutic testosterone are MODULATED by estradiol!
As one of the world’s leading Androgen Researchers and epidemiologists, Dr. Scott Howell has spent the last 2 decades pouring over tens of thousands of studies and has made the same discovery.
Specifically, he came up with five main conclusions:
1. Optimal cellular physiology of sex steroid target tissues vitally depends on the androgen-to-estradiol ratio rather than single hormone action in isolation.
2. This ratio is controlled in vertebrates by aromatase enzyme levels set through the aromatase gene.
3. Alteration of this ratio in either direction leads to pathology of most organ systems.
4. Aromatase is a fail-safe mechanism in men to protect organ systems through the needed levels of estradiol for organ protection relative to circulating endogenous or exogenous androgens.
5. Only 20 cases of true aromatase deficiency or true aromatase excess syndrome has been described in the medical literature since 2014 so there is no justifiable reason to block aromatase in men on testosterone replacement or bodybuilders taking massive amounts of synthetic androgens.
Aromatase Inhibitors: Dangerous Medications You Should Stay Away From
Aromatase inhibitors (AIs) are the #1 go-to drug for any physician who wants to suppress estrogen levels in men.
“This meta-analysis confirms that an aromatase inhibitor (AI) is not the best therapy for all postmenopausal women with hormone-receptor positive, early-stage, breast cancer.
This potentially practice-changing article provides new evidence for AI toxicities, which practitioners should consider when choosing between adjuvant endocrine therapies for postmenopausal breast cancer patients.
The authors conducted the study to clarify why AIs, when compared with tamoxifen, increased disease-free survival but not overall survival.
AI toxicities were suspected to counteract decreased recurrence rates.”
Here is just a small sample of some of the side effects which come with the use of AIs:
It is mediated through local renin-angiotensin system activation in the kidneys and ADH.
In plain English, estrogen is not the problem here.
Any supposed issues around water retention will resolve in 4-6 weeks.
However, it will recur if someone consumes a diet high in sodium and/or carbohydrates and also has high systemic inflammation and visceral body fat from living a poor lifestyle.
Despite what you may have heard, the vasomotor symptoms experienced by women are also present in men:
“Vasomotor symptoms are those that occur due to the constriction or dilation of blood vessels.
They include hot flashes, night sweats, heart palpitations, and changes in blood pressure.
The most likely reason why these symptoms can occur during menopause is that hormonal fluctuations affect the mechanisms that control blood pressure and temperature control.”
One side effect which wasn’t mentioned above are emotional and mood disturbances, which are often tied with so-called estrogen dominance.
<Remember there is no such thing as estrogen-dominance, only insulin resistance and systemic inflammation>
This was disproven in a 2016 study examining two separate cohorts of men with low testosterone from two separate yet randomized trials.
The main purpose of the study was to see how testosterone and estradiol deficiency contribute towards the development of vasomotor symptoms.
One cohort received either a placebo or various doses of testosterone gel for 16 weeks.
The other cohort received either a placebo or the same doses of testosterone gel AND anastrozole (a popular AI) for 16 weeks.
What was the key mediator of vasomotor symptoms?
A LACK of estrogen!
Furthermore, the incidence of vasomotor symptoms was most present in the men who were taking the AI.
This is the best evidence we have to date, and as anybody knows, anecdotes in the bodybuilding industry never really pan out.
The Medical Community Does NOT Understand The Harm Of Blocking Estrogen
To this day, I am still astounded by the number of clinicians who do not READ modern scientific literature and have no clue how to interpret it properly.
Yet many of them will still assert that blocking estrogen is the way to go.
You can’t simply come to this conclusion after reading 1-2 studies and talking to a few “bros” in the gym.
Dr. Scott Howell, one of the foremost world leaders on managing estrogen levels in men, knows FOR A FACT that aromatase should not be inhibited in otherwise healthy men.
In fact, blocking aromatase is extremely harmful in the long run if you are using androgens.
How did he come to this conclusion?
He looked at the totality of the evidence: Animal or mammal studies, case reports, forensic reports, observational studies, dose-escalation studies, toxicology studies, and designs that are closely related.
Dr. Howell also spent 10 years reviewing and compiling case and forensic reports from all over the world, looking at observational studies, trials, and experiments that were conducted on anabolic steroids.
In about a 15-year period, he compiled nearly 30,000 androgen studies from the early 1900s to the present day.
He found that there was NO SUCH THING as a universal “sweet spot” for estradiol levels in men.
“Taking steroids can cause the left ventricle, the main pumping chamber of the heart, to enlarge disproportionately compared to the rest of the heart. This increases chances for irregular heartbeats and sudden death”
And as Dr. Howell put it, “The pathology is characteristically a diffuse collagen infiltration that occurs simultaneously with left ventricular hypertrophy and it happens across the board when estrogen is blocked.”
But I want to dive deeper into this and talk about the five main reasons why bodybuilders are constantly dying of heart problems.
Overloading The Heart Muscle Through Uncontrolled Hypertension
Our heart changes in size, shape and function through a process called “cardiac remodeling.”
Physiologic remodeling takes place when an athlete exerts vigorous effort and it is not considered to be damaging.
Pathologic remodeling, however, takes place when the heart muscle sustains some form of injury.
When you take extremely high doses of AAS and combine them with several hours of exercise per day, you get hypertrophy of the heart’s left ventricle (and the heart overall).
Here’s what I mean…
The physiologic androgens normally found in your body are known to have anabolic effects on your heart cells.
When you “knock out” the receptors these androgens normally bind to, and there is no presence of estradiol produced by aromatase, cardiac growth (i.e. heart growth) does not take place.
However…when you “knock out” the aromatase enzyme, mice studies have shown that the androgens stimulate MORE hypertrophy of the heart muscle.
That’s not where the story ends, especially since you’re using supra-physiologic doses of AAS.
The cardiac remodeling that then takes place involves a peptide known as angiotensin II, which belongs to the Renin-Angiotensin-Aldosterone System (RAAS).
Angiotensin II is responsible for increasing blood pressure by constricting your blood vessels, and is also involved in pathologic cardiac remodeling.
In this remodeling process, an overproduction of collagen (a structural protein found in connective tissues) takes place and the excess gets stored in your heart and arteries.
So let’s recap…
When you have elevated Angiotensin II levels and low estradiol levels, you have uncontrolled hypertension.
That right there is the perfect recipe for cardiac pathology in bodybuilders because you have lost the protection to EVERY organ system offered by estradiol.
When bodybuilders use high-dose androgens and aromatase inhibitors, the cardiac pathology becomes even more extreme in terms of hypertrophy and collagen infiltration.
Put another way, Angiotensin II is a bodybuilder’s worst enemy.
In summation, E2 binding to ERβ and ERα in heart muscle cells is essential to maintain cardiac health.
High doses of androgen will lead to adaptive cardiac hypertrophy that is somewhat reversible, but only if pathologic fibrosis does not occur.
But in the absence of E2 binding, the adaptive hypertrophy from androgens is magnified and begins the progression to pathologic remodeling.
Fibrosis will occur if nothing is done to resolve the underlying stimulus early on during androgen abuse.
Or as Dr. Howell put it: “When high dose androgens are coupled with aromatase inhibitors, progressive fibrosis becomes a critical pathological event in the progression to cardiac hypertrophy and loss of cardiac function.”
Excessive Oxygen Demands From An Unnatural Amount Of Muscle Tissue
As a logical consequence of the first two outcomes, you end up putting a LOT of residual strain on your heart.
Because you’re using supra-physiologic doses of AAS, you are carrying an additional 50-100 pounds of lean muscle tissue (relative to what your natural genetic weight would be).
“Myocardial oxygen demand is the amount of oxygen that the heart requires to maintain optimal function, and myocardial oxygen supply is the amount of oxygen provided to the heart by the blood which is controlled by the coronary arteries.”
How long do you think your heart can keep up with the endless need to supply every tissue with the required amount of oxygen for optimal function?
It can’t pump enough blood, and it cannot do so fast enough to keep the body going.
And the end result is some kind of heart failure.
The Bodybuilder Lifestyle Makes All The Heart Problems So Much Worse
With hours of heavy resistance training, you are further inducing the cardiac hypertrophy mediated by Angiotensin II and the excessive doses of androgens used.
“Our findings support an emerging consensus that the effects of vigorous weight training, combined with anabolic steroid use and increased androgen sensitivity, may predispose these young men to myocardial injury and even sudden cardiac death”
In virtually every single story of a bodybuilder passing away, a heart problem always seems to be at the very root of what caused their untimely death:
“…in all cases the autopsy findings together with the histological examination have highlighted cardiac causes of death.
Only in one casea mechanical cardiovascular cause of death was found (a bilateral pulmonary embolism from deep venous thrombus of lower extremities).
In numerous cases, a common finding was a left ventricular hypertrophy, frequently associated with fibrosis and myocytolisis.”
I think the takeaway so far is fairly obvious.
Supra-Physiologic Dosages of Anabolic Steroids Cause Damage To The Cardiovascular System
Putting aside the estrogen talk for a moment, the androgens being used by bodybuilders come with their own host of damaging side effects.
The interesting part about all this is that the literature enabled the identification of specific toxicity phenotypes in each of these categories.
Each form of toxicity also has a direct injury component through reactive oxygen species and oxidative tissue damage.
How Physicians Can Start Saving Bodybuilders’ Lives
The funny part about solving this issue is how remarkably simple the solution is…
You need to give your body a few weeks to fully adapt to the exogenous administration of testosterone.
All of the symptoms you experience will eventually be resolved and you will be at a new normal.
The only way you would end up having a legitimate insensitivity to testosterone is if you had an extremely rare genetic disorder where your androgen receptors are mutated.
We’re talking about 0.001% of the population — if this is you, you would have known by the time you/ were 5 as your “development” would have been way off.
You need to stop obsessing about hour-to-hour mood changes, and instead evaluate your mood over a longer period of time (I’m talking about 2-3 months here).
Testosterone is NOT a magic bullet and it will not change everything.
This is why tip-of-the-spear physicians encourage new patients on therapeutic testosterone to “ride it out” for a few weeks before making any changes.
Any necessary changes would rarely IF EVER consist of adding an AI to suppress or modulate your estradiol levels.
The right changes are cleaning up your lifestyle (reducing systemic inflammation) and most importantly dropping visceral body fat.
With all this in mind, there are two immediate steps clinicians can take to reduce harm in anabolic steroid users…
1) Take an Angiotensin-converting enzyme (ACE) inhibitor or an Angiotensin Receptor Blocker (ARB).
The two enzymes ACE and ACE2 are responsible for regulating your body’s production of Angiotensin II.
As you already know, elevated levels of Angiotensin II are detrimental to the function of the heart and kidney.
Angiotensin II is made from cardioprotective Angiotensin I through ACE, and so we want to use ACE inhibitors to block this conversion.
Conversely, using an ARB will prevent Angiotensin II from binding to its receptors and exerting its effects.
2) AVOID using AI’s altogether, (if removal due to extreme psychogenic need purposes is impossible)only using them for very short periods of time (2-3 weeks MAX) where goal is permanent titration of therapy)
If you are a man working with a Doctor who has you on an AI, find another Doctor ASAP.
If you are a Bodybuilder utilizing AI’s to limit your ‘perceived side effects’ from supra-physiologic levels of AAS, make sure you read this article over and over again.
But there are some higher powers who have a vested interest in ensuring they never see the day of light.
And if they do, they will be for treating conditions far beyond the scope of their true value.
This sounds like an extraordinary claim if you take it at face value.
Which is why I’m going to take my time and slowly explain how peptides are fading away from clinical use.
Why I’m Focused On Preserving The Peptides Industry
So here’s what has happened in recent times…
One of the world’s most prestigious peptide compounding pharmacies has been put on notice.
They received a ‘warning letter from the Federal Drug Administration (FDA)’ stating that some of the peptides they’ve been prescribing are being taken off the market as they are not FDA-approved:
That’s right – they’ve been synthesizing massively life-enhancing therapeutic peptides for the past 3 years, but no more.
This compounding pharmacy will have to stop producing these select peptides by a certain date to comply with the FDA mandate.
Why would the FDA do this?
If their primary mission is to protect consumers, globally and in the USA, why would they stop the distribution of proven and powerful life-altering medications that can save human lives?
To answer this question, we need to do some deep digging into several topics…
What Are Compounding Pharmacies And Why Do They Exist?
In case you have never heard of a compounding pharmacy, here is a brief description of what they do:
“Compounding is the creation of a pharmaceutical preparation—a drug—by a licensed pharmacist to meet the unique needs of an individual patient (either human or animal) when a commercially available drug does not meet those needs.
A patient may not be able to tolerate the commercially available drug, the exact preparation needed may not be commercially available, or a patient may require a drug that is currently in shortage or discontinued.”
Historically, there used to be a time in history where all drugs were compounded.
You would visit your local apothecary and the pharmacist would make it for you.
Doing so would allow the pharmacist to customize your formulation in a way that best suits you:
Adding flavors to make a drug more digestible (think of a child who hates taking medication)
Increasing or reducing the strength/dosage
Removing certain allergens you may be sensitive to
Altering the medium of the medication (taking a liquid instead of a pill, for instance)
Up until the 1900s, this was the very essence of the pharmacy field.
All of this changed when the Industrial Revolution came about and led to the mass manufacturing and production of standardized formulations.
So if a prescribed drug came in a dosage strength that was too high/low for you, or it had an additive you were allergic to, you were out of luck.
However, there still remained people who had specific and individualized medical needs.
For this reason, compounding pharmacies still existed but were largely left to the wayside.
Funny how history ends up coming full circle to what our much wiser ancestors already know.
Unfortunately, it appears as if most of these compounding pharmacies may not be around for too much longer.
How Are Compounding Pharmacies Being Targeted?
To really get a clear picture of why compounding pharmacies are in jeopardy right now, it is important to understand the two types that exist:
503A Compounding Pharmacies
“those that compound according to prescriptions specific to particular patients and are required by state boards of pharmacy to comply with USP and other guidelines”
“limited to dispensing only for home use and are not allowed to compound large batches, an ability that can lead to lower product costs.”
503B Compounding Pharmacies
“ those with outsourcing facilities that may manufacture large batches with or without prescriptions to be sold to healthcare facilities for office use only.”
“allowed to use larger batches to lower their manufacturing costs, passing the savings onto consumers”
“held to higher regulatory standards…These facilities are required to maintain full compliance with current good manufacturing practices (CGMP).”
As you can deduce from reading the descriptions above, the 503B pharmacies are the ones who would be synthesizing “grey market” peptides.
(FYI – “grey market” refers to a market in which products are distributed through unauthorized channels that do not belong to the original manufacturer)
If a doctor writes a script for a research chemical and then has a compounding pharmacy make it for the patient (assuming it was done under good judgment), the rules are technically being followed.
Now, this is where things get a little tricky.
When you only have a few 503B pharmacies that are operating under the radar without making too much noise, you won’t see the FDA hammering down on them quickly.
As the old saying goes, “We’ve got bigger fish to fry.”
But when too many people become aware of something that could disrupt the establishment, it’s going to get shut down in the blink of an eye.
For instance, if people purposely 10x their dose of a peptide thinking that 10x dose is automatically better, and then the consequent side effects gain enough volume, the FDA is going to take swift action and restrict access to said peptide.
In a weird way, the majority of the human population realistically needs the “mommy/daddy” FDA figure to tell them what to do and how to do it.
So now we have the 30,000-foot view of what happens, but let’s dive in deeper.
How Does The FDA Drug Approval Process Work?
Understanding the onslaught against therapeutic peptides requires you to know how the FDA approves drugs to be marketed and prescribed.
Here is an infographic taken directly from the FDA website that summarizes the process.
This picture also does a great job of showing just how notoriously difficult it is for a single drug to successfully pass through FDA’s drug approval process:
When you allow drugs that don’t go through the FDA process to mix into the public sphere (without their rigorous standard of testing), you compromise the entire system.
The FDA holds a position that until a particular drug product has been vetted to be safe and effective in their eyes, it should not be given to people.
“Off-label” drug use commonly refers to prescribing currently available medication for an indication (disease or symptom) for which it has not received FDA approval.
Off-label use also includes prescribing a drug for a different population or age range than that in which it was clinically tested and using a different dosage or dosage form.
Contrary to what patients might assume, off-label drug use is not the same as experimental or research use. Once a drug is FDA-approved for a specific indication, legally it can be used for any indication.
Off-label prescribing is common; it accounts for 10 to 20 percent of all prescriptions written, although the practice is more common in specific patient populations like children and the elderly.”
Here’s what all of this means:
The ONLY way a doctor can legally (and I do mean 100% legally) prescribe a therapeutic peptide for off-label use to a patient is if the peptide itself is already FDA approved for an existing medical condition.
And when doing so, they would hopefully be operating within the bounds of good medicine and using sound clinical judgment.
From a legal standpoint, it may not be a top priority for the FDA to hunt down doctors who are prescribing unapproved peptides to their patients.
But it would not be classified as a legal action, and one would argue this practice continues to happen due to a lack of enforcement.
The word ‘peptide’ isn’t the issue…it’s whether a drug substance is FDA approved or not.
This would therefore mean that SOME of the stuff made by SOME of the compounding pharmacies are not entirely legitimate (i.e. peptides which are dubbed as ‘research chemicals’).
Such is the nature of the game – you have to play within a closed circuit and follow the rules.
The Latest FDA Move That May Be A Death Sentence For Therapeutic Peptides
I informed my private circle of close friends about some horrifying news which would affect therapeutic peptides:
“As some insulin, human growth hormone and other products transition on 23 March from new drug applications (NDAs) to biologics license applications (BLAs), the recently passed government spending bill included a further tweak to add new proteins to the transition.
The NDA to BLA change effectively means that any follow-on products for these NDAs will need to win approval as biosimilars after [March 23, 2020]. The transition was created by the Biologics Price Competition and Innovation Act of 2009, which clarified the statutory authority under which certain protein products will be regulated by amending the definition of a “biological product” to include a “protein (except any chemically synthesized polypeptide).”
For a comprehensive list of the drugs the FDA plans to transition towards being classified as BLAs, go here.
“What this means is that pharmacies will no longer be able to compound HCG [human chorionic gonadotropin] without a “Biologics License”.
Conventional pharmacies that compound and dispense medications fall under the 503A pharmacies under the FD&C Act. In short, these 503A pharmacies will not be able to acquire a “Biologics License” and therefore they will not be able to compound HCG.”
We’re not just talking about HCG…mendropins, follicle-simulating hormone, hyaluronidase — every peptide you saw on the FDA list can no longer be compounded into medical formulations.
“The drug is safe and effective for the proposed use and that the benefits outweigh the risks
The labeling is appropriate and contains all necessary information about the drug
Manufacturing methods preserve the drug’s identity, strength, quality, and purity”
However, here is where the difference lies between the two:
“because biological products are processed from living material, BLA content must also demonstrate purity specifically in terms of showing that the final product does not contain extraneous material.
Due to the complexities of manufacturing biological products, a pre-license inspection of the facility is generally required before a BLA is approved. Pre-approval inspections sometimes also take place during an NDA review, but are typically conducted based on risk assessment by the Agency.”
Want to know how expensive an APPLICATION for a BLA is?
“…the telomeric differences between humans and laboratory mice have led scientists to underestimate the risks new drugs pose to humans in the form of heart disease, liver dysfunction, and related organ failure”
“…captive-rodent breeding protocols, designed to increase reproductive output, simultaneously exert strong selection against reproductive senescence and virtually eliminate selection that would otherwise favor tumor suppression.
With their telomeric failsafe effectively disabled, these animals are unreliable models of normal senescence and tumor formation.
Safety tests employing these animals likely overestimate cancer risks and underestimate tissue damage and consequent accelerated senescence.”
“We try to control everything we can possibly think of, and as a result we learn absolutely nothing.
Garner argues that research based on mice would be more reliable if it were set up more like experiments in humans — recognizing that variation is inevitable, and designing to embrace it rather than ignore it.
…using animals as models of disease is a big reason that many results in biomedical research aren’t readily reproducible.”
Perhaps this finding invalidates certain types of studies, while others are still legitimate.
But until we can acknowledge this, comprehensively prove it and make changes to address the issue, there is no definitive way to know.
Examples Of Therapeutic Peptides That Are Superior To Conventional Medical Approaches
There are two reasons I can think of for any desire to ban therapeutic peptides from getting in the hands of everyday people.
Either they are so incredibly dangerous to the point where they can’t be used productively, or
They are so insanely effective to the point where they can hurt the profits made by existing medical treatments that are inferior in nature.
I’m betting on the latter, and I’ll show you why with some concrete examples.
Multiple compounding pharmacies were making this peptide and it was very affordable for patients to use.
Sermorelin was thought to be superior to ordinary human growth hormone (HGH) injections that attempted to merely replace a lack of HGH in the body through exogenous administration.
Unlike these injections, Sermorelin acts by helping the body naturally secrete more HGH and release to parts of the body where it is most needed.
This happens because its effect is identical to Growth Hormone-Releasing Hormone, which stimulates the pituitary gland to increase HGH production.
On top of being safer and carrying a far lower risk for side effects, it also provided numerous health benefits (this list is just a very small sample):
“Sermorelin enhances the Pituitary Gland’s natural ability to produce endogenous Human Growth Hormone, leading to a more natural Hormone Profile
Sermorelin optimizes the human body, increasing physical and mental performance
Sermorelin strengthens immune health
Sermorelin boosts the liver’s production of Insulin-Like Growth Factor One
Sermorelin helps patients sleep longer, deeper, and better”
However, its production was sadly discontinued in 2008“due to difficulties in the manufacturing process of the active ingredient used to produce commercially supplied sermorelin but not due to safety issues.”
And Sermorelin is listed as a banned substance in sports organizations such as WADA and USADA for its anabolic effects, which likely incentivized its discontinuation.
Granted, there are several other HGH-producing peptides that have come into existence and demonstrated favorable results.
But you have to wonder why such an effective biomolecule was suddenly made unavailable1
Cerebrolysin is one of the peptides I plan to feature in my upcoming book about using therapeutic peptides to achieve optimal health.
Tesamorelin is a different beast as it is technically FDA-approved.
Specifically, its brand name is Egrifta and it was approved in 2010 for HIV-positive patients with lipodystrophy (i.e. a condition where the body has excessive abdominal fat due to its inability to properly utilize and store fat tissue).
This indication came about because lipodystrophy was one of the major side effects that came with using highly active antiretroviral therapy (HAART) drugs.
“…[they are] state-run programs which collect and distribute data about the prescription and dispensation of federally controlled substances and, as the individual states deem appropriate, other potentially addictive or abusable prescription drugs.”
A PMP allows you to track all of the drugs being used, who is prescribing them, the person they’re prescribed to, the indication they’re used for, and everything else you could want to know about how your drug is being distributed.
Realistically, the alarms won’t sound if you see just a handful of doctors using a competitive peptide off-label.
But beyond that, it’s time to have a “quiet” conversation with the guilty doctors.
You legally intimidate them, pressuring them to stop using the peptide for off-label purposes or else the peptide will no longer be supplied to their pharmacy.
If you don’t want to be the bully yourself, you can call the FDA!
You just ring them up and say “We saw these doctors using the peptide for conditions not approved for with our drug, and based on our data we do not approve of this.”
The FDA calls those doctors and asks them why the drug is being prescribed for an ailment which is not recommended by the manufacturer.
I could go on, but there are many different ways to exert a lot of pressure on doctors who dare to deviate from the sick care model of healthcare.
This is not the “grand conspiracy theory” many health researchers believe it is, but pure economics and psychology in action.
It’s a natural feedback loop in which people will do whatever it takes to make as much money as possible in the free market society, even if that means suppressing a superior solution.
Most of humanity is sadly asleep and low conscious — they are not going to push back and fight against a system they are unconsciously dependent on.
How The FDA’s Efforts Will Create A Black Market For Therapeutic Peptides
So with therapeutic peptides out of the picture, where else are people going to get them?
“Grey goods are legitimate goods that come from the correct manufacturer, but they are sold through unauthorized channels. While these are not illegal goods, it is important to be wary of them. Sellers who use the grey market will usually sell products that have been improperly discarded due to damage or product recall.”
“Black market goods are items that are illegal to manufacture or sell. Some black market goods are counterfeit, and some are genuine products that are simply illegal to own or distribute. These are usually a part of a separate, more obscure market than grey goods.”
Without any form of regulation, malicious sellers can get away with selling over-priced peptides that are impure and contaminated:
“As a result, the final price on gray market–traded drugs may be as much as hundreds of times higher than the price that the manufacturer originally received for the product.
Also, as the drugs bounce along the extended supply chain, they may be improperly repackaged, re-labeled, and possibly stored under unsuitable conditions, as well as replaced by counterfeits, compromising their integrity and safety.”
Combine this with the lack of knowledge from the consumer and you have a recipe for disaster.
“Due to drug shortages, 52 percent of hospital supply chain employees and pharmacists have been forced to buy drugs from the “gray market,” according to ISMP research.
The gray market consists of drug suppliers that are somehow able to obtain supplies of scarce drugs and sell them at exorbitant costs, sometimes with mark-ups as high as 650 percent, according to previous studies.”
This is the reality we will soon face unless massive and immediate action is taken.
But there’s just one more hurdle we have to deal with…
We Have VERY Few Physicians Who Can Competently Prescribe Peptides
When you do a head count of all the physicians who are certified and well-trained to safely administer therapeutic peptides, you’re talking about a couple hundred at best.
This is an extremely niche area of medicine which requires extensive training and knowledge you won’t get in 4 years of medical school.
And there are very few highly-accredited teaching bodies in existence:
The few peptide physicians in existence have had to put a significant amount of time and money towards obtaining their fellowship training in peptide therapy.
They have the first-hand experience, the connections to legitimate compounding pharmacies, and the testimonies from thousands of patients who can attest to both their doctors and the life-changing benefits of therapeutic peptides.
But without the FDA allowing the use these peptides, these doctors will not have the tools necessary to properly care for their patients.
What You Can Do To Save The Future Of Therapeutic Peptides
We need to collectively come together and do everything we can to stop the FDA from suppressing the use of therapeutic peptides altogether.
So here are some action steps you can take immediately to do your part and have your voice heard.
First, go to SavePeptides.org and tell the world how therapeutic peptides have changed your life for the better.
Every single submission matters, so spare no details in telling the world why we MUST keep these miraculous compounds available for human use.
Staying on the sidelines with off-label use is no longer acceptable!
Second, you can contact the FDA and explain why banning therapeutic peptides will negatively impact the lives of tens of thousands of people.
This website provides you with a good starting template if you need assistance with writing a thoughtful reply.
Third, you always have the option of getting your peptide of choice approved through the IRB process.
This is not a perfect approach and it is extremely expensive and time-consuming.
But if this actually works in your favor, you can have a reputable compounding pharmacy make the peptide for your intended purpose.
Fourth, make sure you support the organizations that work tirelessly to keep the clinical use of peptides alive and running.
All the organizations I listed in the previous section are doing tremendous work in advancing the scientific research of peptides, both old and new.
Just because peptides are currently unapproved by the FDA or used off-label DOES NOT mean that they are inherently unsafe!
Fifth, and finally, share the videos and podcasts I have released on the subject of therapeutic peptides.
The more people know about what therapeutic peptides can do, the better society will be.
This Podcast is the BEST EVER DONE on understanding how to use therapeutic peptides for nearly every conceivable clinical indication.
Let’s not forget the amount of fructose you would be consuming, which would cause an inflammatory insulin response depending on your body composition and genetics.
If you are getting a maintenance dose of ascorbic acid while healthy(not experiencing symptoms), there’s nothing wrong with getting your Vitamin C from whole foods (Although realistically, it would still be tough to hit maintenance dosage with citrus fruits and you’d be consuming a lot of fructose).
Vitamin C IS Ascorbic Acid!
By far, the biggest myth worth debunking is that ascorbic acid and Vitamin C are entirely separate things.
This is an agenda pushed by people who are trying to sell “Whole Food” Vitamin C supplements.
“The proponents of this idea believe that vitamin C is a complex consisting of 5 ‘circles’.
The elements within those 5 ‘circles’ may include ascorbic acid, ascorbigen, factor J and factor P; as well as Tyrosinase & copper.
Sometimes you will see rutin listed together with ascorbigen, and factor K and choline listed together with factors J & P.
…Contrary to what most people believe, the molecular structure between synthetic ascorbic acid, and ascorbic acid made naturally in plants and animals are identical.
In standard scientific literature, this imaginary 5 ‘circle’ Whole Food C complex does not exist.
The individual elements, all except factor J, have clearly identified roles in biochemistry, and their biological functions are quite different in plants and animals.”
(I strongly recommend reading the entire post, which investigates the supposed science behind these false claims)
If you look at any study describing how plants and animals make ascorbic acid, they are referring to Vitamin C.
All of this is a long way of saying that ascorbic acid and Vitamin C are the EXACT same thing!
And don’t be fooled by people who try to tell you there are differences between “natural” and “synthetic” ascorbic acid.
Studies have consistently shown they are identical, both in bioavailability and biological activity.
The Only 3 Types Of Ascorbic Acid You Need
If you are using Vitamin C to treat a COVID-19 infection, it is extremely important to select the RIGHT type of Vitamin C.
You also want to avoid any mainstream disinformation outlet who convinces you to avoid using Vitamin C through fear-inducing propaganda:
“A new report from Yonder, a company that dissects popular social media interactions to understand trends, has found that stalwart anti-vaxxers are pushing a narrative that vitamin C can prevent COVID-19.
There is currently no evidence that vitamin C is a treatment or cure for the coronavirus.”
In fact, there are numerous mainstream physicians, researchers and thought leaders advocating the usage of Vitamin C to treat COVID-19 including:
I also received an amazing testimonial from someone who has personally had great success with using Vitamin C:
“Within 4-5 days the 2 guys with the strict protocol of oral Ascorbic Acid diminished all the symptoms to a very light cough. Within 7 days, no cough and brought the Asorbic down to 6-8k grams daily.
The guy that did the same IV treatment but didn’t want to take the oral, because he’s a hard head, still has the dry cough and had a big episode of cough and light chest pain 2 days after he stopped the IV.
So the Asorbic protocol works and stops the Covid dead on its tracks, i know it, and also protects you if you dont have symptoms.
I have distributed Vit C to around 30 people including family, employees, and friends and i see the wonders it does.”
With so many influential people advocating Vitamin C, anyone dismissing it with statements like “it’s not scientifically proven” or “where are the studies” are only part of the problem and offer nothing toward the solution.
Dismiss such low vibration humans with extreme prejudice and remember those who are contributing to solving the Covid-19 crisis.
Vitamin C in pure ascorbic acid form orally and for severe infections, a combination of oral and IV Sodium Ascorbate is proven to work.
Here are the 3 types of Vitamin C you should have on deck for treating COVID-19:
Pure Ascorbic Acid Powder
This is the best form of ascorbic acid out of the three.
It will be instantly absorbed by the body and fast assimilation will ensure super-saturation of your red blood cells.
High dose ascorbic acid is critically important for proper immune function as it shuts down cytokine storms while enhancing the supply of blood oxygen (via formation of nitric oxide) when COVID-19 is attacking the heme in red blood cells.
First, if you are on a low-sodium diet, you may have some difficulty with maximally absorbing pure ascorbic acid. In this case, taking a tiny pinch of sea salt with every other dose of ascorbic acid should be sufficient. Individuals who consume normal or higher levels of sodium in their daily diet will not need it (just be very careful if you have hypertension).
Second, people with stomach issues (i.e. not enough stomach acidity) may require a buffered form.
An alternative would be to consume ascorbic acid with an acidic beverage — or anything that will increase stomach acidity.
“50 million grams [i.e. 50 TONNES]. That is how much vitamin C was sent to Wuhan to help their citizens fight COVID-19 on Feb 2nd, 2020.
This is taken from a TWEET by DSM, major manufacture of ascorbic acid in Jiangshan China.
Royal DSM, is a global science-based company in Nutrition, Health and Sustainable Living that has established a state-of-the-art manufacturing site in Jiangshan.
DSM is the same company that produces high quality ascorbic acid known as Quali-C in Scotland.
According to a trusted professional source, the products from China is of the same quality, but cannot be called ‘Quali-C” due to trade-mark rights”
The differentiating factor is the quality control upheld by each manufacturer.
Even if you choose the same manufacturer, you cannot consistently expect the same level of quality.
Your best bet is to rely on the importer and the retailer who conduct quality control studies to verify the purity of each ascorbic acid shipment.
Therefore, you should source your ascorbic acid from a larger and more reputable company who has the money and manpower to enforce stricter quality control standards.
Outside of this, they are all the same.
Ascorbic acid is the easiest natural supplement to make and the cheapest for consumers to buy.
As long as you source it correctly, you won’t go wrong!
My Recommended Sources For Buying Ascorbic Acid
I’m currently working with my Aseir Custom business partner Nick Andrews on having my own specific pure ascorbic acid products to help people get massive quantities of pure ascorbic acid at an affordable cost.
In the meantime, here are your next best choices for buying ascorbic acid in a red-hot market.
“…the [list of conditions approved for HBOT] also includes osteomyelitis, sudden hearing loss, burns, severe anemia, carbon monoxide poisoning, decompression sickness, necrotizing soft tissue infections, crush injuries and arterial gas emboli.
In the majority of these conditions, hyperbaric oxygen is utilized as an adjunct to mainstream treatment. In the case of chronic wounds, this includes debridement, infection control, specialized dressings and offloading.”
Research estimates the HBOT market will be worth $3.91 billion by 2025, with 30,000 treatments performed per year.
This begs the question of why HBOT is becoming the latest interest of biohackers around the world.
In order to provide a complete answer, we must first understand why oxygen carries such great importance for fully optimized health.
Why Is Oxygen So Essential For Human Health
Oxygen is the most important substance for proper bodily function and survival.
“Increasing your oxygenation levels and being fit and healthy has shown to be important for your health as optimum oxygen levels can improve wound healing, vision, mental clarity and intelligence, boost your immune system, help fight cancer cells, reduce stress levels, improve your heart and respiration and help you to lose weight.”
But is there such a thing as “too much” oxygen?
What Is The Optimal Dose Of Oxygen For Better Health?
We can generally divide the dose for any nutrient into 3 ranges:
Recommended Daily Amount (RDA): The minimum amount required before we express obvious disease or dysfunction as a result of deficiency.
Optimal Range: The amount required to ensure we have enough of the nutrient to fulfill the complex biological processes taking place within our body.
Megadose: Certain situations call for much higher doses to help our body overcome a health problem.
When you think about it, virtually all forms of disease and dysfunction can be reduced to either a deficiency or toxicity.
This goes beyond nutrients – the concept applies equally to our emotional resilience and the way we move our bodies.
In order to achieve peak performance health, we need to get rid of anything which sabotages our efforts towards reaching that state.
If we are toxic, we have an excess of something our body needs to get rid of.
If we are deficient, we are missing something our body requires to perform optimally.
Let’s use this understanding to deduce the right amount of oxygen for optimal health…
An oxygen deficiency is known as hypoxia, a condition where the body cannot efficiently absorb or deliver oxygen to our cells.
Hypoxia can either be systemic yet it can also be local to a specific tissue type or organ.
“…the response by gene expression to changes in oxygen is directly coupled to oxygen levels in the animal cell, allowing immediate cellular responses to occur to oxygenation through the action of the HIF transcription factor”
Oxygen Absorption Below Sea Level
The phenomenon described for high altitudes works the opposite way in lower altitudes.
As we descend below sea level, the pressure increases and therefore our ability to absorb air and oxygen also increases.
Pretty straightforward, right?
Here’s where HBOT sets itself apart from other oxygenation methods.
We can actually control the amount of pressure exerted on a person and the amount of time spent in this pressurized environment.
Therefore, HBOT helps the practitioner predictably control the amount of increased oxygen absorption a patient can take into their cells.
Once absorbed, this “extra” oxygen can be used for making ATP and energy, increasing the capacity for working tissues to perform (or increase the capacity of healing and recovery).
This induces a state called hyperoxia, a state where the body has a greater supply of oxygen than necessary.
“The high level of oxygen in the blood allows improved oxygen delivery to tissues that are not getting enough oxygen at baseline (i.e. hypoxic tissues).
Having times of alternating hyperoxia and hypoxia (as occurs during a series of HBO treatments) promotes the growth of new blood vessels into the hypoxic tissues, a process known as neovascularization.
Hyperoxia enhances the body’s ability to kill certain bacteria.”
In other words…
Through by-passing the red blood cells and absorbing oxygen directly into our plasma and tissues while in a chamber, we increases oxygen absorption by 28-40%.
If you want to understand the concepts discussed in greater detail, I highly recommend watching this short primer video on HBOT:
The Most Important Health Benefits Of Hyperbaric Oxygen Therapy
With a full understanding of how HBOT works, the health benefits it provides to patients are fairly obvious.
Even though 120 reported conditions (and counting!) are proven to be effectively treated by HBOT, here are the 5 most important ones:
“With the 2019 coronavirus COVID-19 pandemic, it’s especially important to understand that no supplement, diet, or other lifestyle modification other than social distancing and proper hygiene practices can protect you from COVID-19.”
“High dose IV vitamin C has been used in China to help improve lung function in people with COVID-19. However, vitamin C’s effectiveness is still being tested. There’s no evidence to support the use of oral vitamin C supplements for COVID-19.”
(FYI – I frequently link to Healthline’s articles when I’m writing content, but I really think they missed the mark on this one)
Even the World Health Organization refuses to acknowledge the possibility of Vitamin C treatment, opting to spend its resources on clinical trials for other drugs that may not have the same level of efficacy.
To make a long story short, Big Pharma doesn’t give shit about human health.
Their only concern is making money and profiting off disease through the sale of their expensive drug interventions.
Vitamin C will never be approved by the orthodoxy of Big Pharma as there is no patent opportunity nor financial incentive as Ascorbic Acid is dirt cheap to manufacture.
If you wait for the higher echelons of mainstream media and Big Pharma-owned doctors to offer their stamp of approval”on Vitamin C, it will already be too late.
“..his group treated ~50 cases of moderate to severe cases of COVID-19 infection with high dose intravenous (IV) Vitamin C.
The IV Vitamin C dosing was around 10,000-20,000 mg a day for 7-10 days, with 10,000 mg for moderate cases and 20,000 for more severe cases by the pulmonary status (mostly the oxygenation index) and the coagulation status.
All patients who received IV Vitamin C improved and there was no mortality.
Compared to the average of 30-day hospital stay for all COIVD-19 patients, those patients who received high dose IV Vitamin C had a hospital stay that’s about 3-5 days shorter than the overall patients”
“…[Biochemistry professor Peter McCaffery] said that even if IV vitamin C worked to shorten or cure COVID-19, it would likely only be a stop-gap before therapies directed at the virus, such as vaccinations, took over”
Yeah, good luck waiting all the way until next year for a mass-produced vaccine:
“Tests like these are taking place much quicker than would normally be the case, and some are using new approaches to vaccines. It follows that there are no guarantees everything will go smoothly.
But even if these – or any other tests – do prove successful, it’s not expected that manufacturers will be able to produce a mass-produced vaccine until the second half of 2021.”
If people followed the greed of Big Pharma and harmful advice of quack academics by sitting on their hands until 2021 to inject a poorly designed and understood vaccine, millions will likely die.
The Relationship Between SARS-CoV-2 and ARDS
So how exactly does absurdly high doses of Vitamin C (i.e. ascorbic acid) work to stop COVID-19 from doing more damage?
The Direct Connection Between Ascorbic Acid And Coronavirus
The connection between SARS-CoV-2 and ARDS is clear, but where does Vitamin C fit into the picture?
Allow me to explain in layman’s terms…
Our body contains special types of white blood cells called macrophages, which are responsible for consuming and destroying harmful organisms and cellular debris.
As you can imagine, they are an essential part of our immune response.
In 2002, a pivotal study done in peritoneal cells of mice (i.e. membrane cells located on a thin layer of tissue within the abdomen) examined how ascorbic acid concentration in the cells change when oxidative stress increases.
Specifically, the study was looking at macrophages and other cells responsible for making our immune system functional:
Just take a look at the bars corresponding to “M” (macrophages).
You would think that macrophages are unable to accumulate ascorbic acid.
Not true — it turns out the macrophages exposed to oxidative stress, can accumulate, recycle and reuse ascorbic acid 100 times faster than they normally would.
These macrophages also use ascorbic acid to generate nitric oxide (known to improve blood flow), which is why ascorbic acid has such low concentrations in macrophages.
The Optimal Vitamin C Dosing Protocol For Combatting COVID-19
Doris Loh, one of the world’s TOP Vitamin C researchers, suggests the following interventional protocols for oral ascorbic acid in adults:
I STRONGLY recommend reading both of her articles about the connection between Vitamin C, ARDS and SARS-CoV-2 (here and here).
Please watch the profound live stream I did with her Friday April 3rd that provides the scientific research proving the mechanism of action of Ascorbic Acid in fighting Covid-19 and Acute Respiratory Distress Syndrome (ARDS).
Additionally, I’ve created my own video to recap Doris’s Ascorbic Acid dosing protocols listed above.
A Comprehensive Collection Of ALL MY COVID-19 Survival Intel
I can’t tell you what the future holds for the coronavirus.
There is NO telling what new intel may come our way.
But there’s only so many links I can add – both to world-class researchers around the world and to my own material.
So here’s a must-have compilation of all my publicly released content about COVID-19.
I recommend following the instructions found in this graphic for the ‘essential nutraceutical’ interventions.
“The coronavirus pandemic, which has infected more than 30,000 people in New York City, is beginning to take a toll on those who are most needed to combat it: the doctors, nurses and other workers at hospitals and clinics.
In emergency rooms and intensive care units, typically dispassionate medical professionals are feeling panicked as increasing numbers of colleagues get sick.”
This is not a “hoax” – I recently hosted a tell-all interview with an emergency medical responder in his prime who got knocked out by COVID-19 for 7 days straight.
Even people who have minor symptoms and injuries are refusing to go near a hospital, and rightly so.
And if you look at the graph above, it is undeniably clear that SARS-CoV-2 is spreading at an exponential rate.
Proposed Methods For Preventing SARS-CoV-2 And Minimizing Bodily Damage
Health officials and organizations worldwide are scrambling to find new medications and novel uses of existing medications to treat SARS-CoV-2
For example, a recent study was published outlining how a protocol of hydroxychloroquine and azithromycin was effective in a small sample of patients (an antimalarial drug and an antibiotic, respectively).